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Psoriasis is a chronic, systemic, immune-mediated skin disease affecting 2-3% of the global population, characterized by hyperproliferative keratinocytes and associated with significant comorbidities. Despite advancements in biologic therapies, the need for more accessible, effective, and personalized treatment options persists.
Blockchain technology is revolutionizing the pharmaceutical supply chain by addressing critical issues such as obsolete medications, tracking difficulties, and lack of transparency. By providing a decentralized, immutable ledger system, blockchain enhances drug traceability, prevents counterfeit products, and improves overall supply chain management.
This review provides a comprehensive overview of the different classes of phytocompounds that have been studied for their potential in psoriasis management, including HaCaT cell inhibitors, anti-proliferatives, cytokine inhibitors, cyclooxygenase-lipoxygenase inhibitors, pathway targets, interleukin inhibitors, and JAK- STAT pathway inhibitors. Studies have demonstrated the ability of these phytocompounds to modulate key pathogenic pathways involved in psoriasis, such as inflammation, cell proliferation, and cytokine production.
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